Table 4. Factors associated with amputation.

	Amputation (N = 11)	No amputation (N = 42)	Bivariable analysis		Multivariable analysis
			HR (95% CI)	p	HR (95% CI)	p
Fibula/tibia fx	8	14	4.11 (1.09-15.49)	0.037
Open fx	10	15	13.73 (1.76-107.44)	0.013	20.89 (1.27-343.96)	0.033
Contamination	5	3	5.78 (1.75-19.07)	0.004
Soft tissue	8	12	5.31 (1.41-20.05)	0.014
Shock	4	6	4.80 (1.38-16.66)	0.014	9.11 (1.709-48.96)	0.01
IA duration (day)	0 (0-2)*	0 (0-0)*	1.32 (1.06-1.65)	0.013
pRBC-T (unit)	34 (8-50)*	18 (6-22)*	1.03 (1.01-1.06)	0.01	1.05 (1.01-1.10)	0.01

Cox proportional-hazards regression analysis of amputation.

* The data were expressed as median (IQR).

CI, confidence interval; fx, fracture; HR, hazard ratio; IA, inotropic agent; IQR, interquartile range represents the distance between the 25th and 75th percentiles; pRBC-T, amounts of pack red blood cell transfusion.