Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 4;18(11):4301–4315. doi: 10.7150/ijbs.66224

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

DLEU1 competitively bound miR-149-5p in CCA. (A) DLEU1 was affirmed to be principally expressed in cytoplasm. (B) MiRNAs levels following DLEU1 interference (two-way ANOVA). (C) MiR-149-5p level was downregulated in CCA tissues (t-test). (D) MiR-149-5p level was inversely linked to DLEU1 level (linear regression). (E) MiR-149-5p level in CCA cells and biliary epithelial cells (one-way ANOVA). (F-H) The function of miR-149-5p on growth, invasion, and stemness maintenance were revealed by EdU, transwell and spheroid formation assays (t-test). (I) MiR-149-5p mimics restrained luciferase activity of DLEU1 wild-type plasmid rather than mutant-type plasmid (t-test). (J) DLEU1 level was higher in AGO2 groups with miR-149-5p mimics (t-test). ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.