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. 2022 Jul 4;18(11):4301–4315. doi: 10.7150/ijbs.66224

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DLEU1 boosted CCA development via miR-149-5p/YAP1. (A) YAP1 inhibition generated via silencing DLEU1 was rescued via knocking down miR-149-5p (t-test). (B) YAP1 overexpression caused by DLEU1 upregulation was rescued via upregulating miR-149-5p (t-test). (C-G) Suppression of proliferation, invasion, stemness maintenance and chemo-resistance generated via silencing DLEU1 was rescued via miR-149-5p inhibitor in QBC939 (t-test and two-way ANOVA). (H-L) Decreased YAP1 saved the facilitation of proliferation, invasion, stemness maintenance and chemo-resistance caused via DLEU1 overexpression (t-test and two-way ANOVA).^*p < 0.05, ^**p < 0.01.