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. 2022 Jul 4;18(11):4388–4399. doi: 10.7150/ijbs.69890

Figure 1.

Figure 1

PD-L1 deficiency prevents wound healing and upregulated inflammatory cytokines. (a, b)Expression of PD-L1 during wound healing detected by IHC and Western Blot. (c, d)Representative photographs showing macroscopic excisional wound closure of wildtype and PD-L1-/- C57 BL6 mice subcutaneously injected with PBS or 10 μg LPS. (e, f) Representative H&E-stained sections of LPS- or PBS-injected excisional wounds at day 7, arrows indicate wound margins (scale = 500 μm). Analysis of histological wound width reveals LPS or PD-L1-/- significantly delays healing compared with PBS control wounds. n = 5-6 mice/group; (g, h) PD-L1 deficiency up-regulate the expression of TNF and IL-6 during wound healing. *p<0.05, **p < 0.01.