. 2022 Jul 4;18(11):4432–4451. doi: 10.7150/ijbs.73093

Table 1.

Roles of m⁶A writers in human cancer

	Cancer	Role	Expression	Target genes	Source of experimental evidence	Ref
METTL3	BLC	Oncogene	Up	PTEN, AFF4/NF-KB/MYC, SETD7/ KLF4, ITGA6	BLC tissues and cells, mouse	9, 73-75
	BRC	Oncogene	Up by HBXIP	miR-let-7, P21, miR-221-3p, KRT7	BRC tissues and cells	76-79
	CC	Oncogene	Up	HK2/YTHDF1, RAB2B, RAGE	CC tissues and cells, mouse	10, 80, 81
	CRC	Oncogene	Up	GLUT1/mTORC, miR-1246/SPRED2 /MAPK, IGFBP2, YPEL5, CCNE1	CRC tissues and cells, mouse	82-86
	ENC	Oncogene	Up	Akt	ENC tissues and cells, mouse	87
	ESCC	Oncogene	Up	Notch, APC	ESCC tissues and cells, mouse	88, 89
	GBM	Tumor suppressor/Oncogene	Down/Up	SRSF, ADAR1	GBM tissues and cells, mouse	90-92
	GC	Oncogene	Up by H3K27ac	HDGF/IGFBP2/GLUT4/ENO2, ZMYM1/Hur/CtBP/LSD1, MYC, miR-17-92/PTEN/TMEM127	GC tissues and cells, mouse	93-96
	HCC	Oncogene	Up	FOXO3, SOCS2, Snail, CRNNB1	HCC tissues and cells, mouse	97-99
	LC	Oncogene	Up	JUNB, miR-143-3p/VASH1	LC cells	100, 101
	NSCLC	Oncogene	Up	MALAT1/miR-1914-3p/YAP, ABHD11-AS1, ATG5/7	NSCLC tissues and cells, mouse	102-104
	OSCC	Oncogene	Up	c-MYC/YTHDF1, BMI1/IGF2BP1	OSCC tissues and cells, mouse	105, 106
	OST	Oncogene	Up	ATAD2	OST cell	107
	OVC	Oncogene	Up	miR-126-5p/PTEN/PI3K/Akt/mTor, miR-1246/CCNG2	OVC tissues and cells, mouse	108, 109
	PRC	Oncogene	Up	Akt, ITGB1, USP4	PRC cells, mouse	110, 111
	PTC	Tumor suppressor	Down	c-Rel/IL-8	PTC tissues and cells, mouse	112
	RB	Oncogene	Up	PI3K/Akt/mTOR	RB tissues and cells, mouse	113
	RCC	Oncogene	Up	ABCD1	RCC tissues and cells, mouse	114
METTL14	AML	Oncogene	Up by SPI 1	MYB/MYC	AML cells, mouse	115
METTL14	BLC	Tumor suppressor	Down	Notch1	BLC tissues and cells,	116
	BRC	Oncogene/Tumor suppressor	Up/down	CXCR4/CTP1B1,	BRC tissues and cells, mouse	11, 117, 118
	CC	Tumor suppressor	Down	Akt	CC cells, mouse	87
	CRC	Tumor suppressor	Down	miR-375, lncRNA XIST, SOX4	CRC tissues and cells, mouse	119-121
	GC	Tumor suppressor	Down	PI3K/AKT/mTOR	GC tissues and cells, mouse	122, 123
	HCC	Tumor suppressor	Down	DGCR8/miR-126, EGFR/PI3K/AKT	HCC tissues and cells, mouse	52, 124, 125
	NSCLC	Oncogene	Up	Twist	NSCLC tissues and cells	126
	OST	Tumor suppressor	Down	cas3	OST tissues and cells	127
	PAC	Oncogene	Up	PERP, mTOR	PAC tissues and cells, mouse	128, 129
	RCC	Tumor suppressor	Down	BPTF, lncRNA NEAT1	RCC tissues and cells, mouse	130, 131
WTAP	AML	Oncogene	Up	Hsp90	AML cells and mouse	132, 133
	CHC	Oncogene	Up	MMP7/MMP28	CHC tissues and cells, mouse	134
	ENC	Oncogene	Up	CAV-1/NF-κB	ENC tissues and cells	135
	GBM	Oncogene	Up	EGFR	GBM tissues and cells, mouse	136, 137
	GC	Oncogene	Up	HK2	GC tissues and cells, mouse	138, 139
	HCC	Oncogene	Up	ETS1/p21/27	HCC tissues and cells, mouse	140, 141
	OST	Oncogene	Up	HMBOX1/ PI3K/AKT	OST tissues and cells, mouse	142
	PAC	Oncogene	Up	Fak	PAC tissues and cells, mouse	143
	RCC	Oncogene	Up	CDK2	RCC tissues and cells, mouse	144
KIAA1429	BRC	Oncogene	Up	CDK1	BRC tissues and cells,mouse	145
	GC	Oncogene	Up	c-Jun	GC tissues and cells, mouse	146
	GCT	Oncogene	Up	DNA repair	GCT tissues and cells, mouse	147
	HCC	Oncogene	Up	GATA3/HuR	HCC tissues and cells, mouse	60
	NSCLC	Oncogene	Up	DAPK3	NSCLC tissues and cells,mouse	148
	PRC	Oncogene	Up	Lnc CCAT1 and CCAT2	PRC tissues and cells	149
ZC3H13	CRC	Tumor suppressor	Down	Ras-ERK	CRC tissues and cells	150
METTL5	BRC	Oncogene	Up		BRC tissues and cells	151
METTL5	GC	Tumor suppressor	Down		GC tissues	152
METTL16	GC	Oncogene	Up	CDK1	GC tissues and celle,mouse	153