Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 4;18(11):4341–4356. doi: 10.7150/ijbs.71134

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

A potential role of VIP/VIPR1 signaling in regulating arginine metabolism and pyrimidine biosynthesis of HCC. Transcriptome sequencing analyses of Huh7 cell (Huh7-Ctrl), and VIP/VIPR1 axis activated Huh7 cell (Huh7-activation). (A) Volcano plot showed differentially expressed genes (DEGs) between two groups (1928 up-regulated genes; 123 down-regulated genes). (B) Gene Ontology (GO) enrichment analysis was performed on DEGs. (C) Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed on DEGs. (D) Heatmap showed increased expression of arginine synthesis and urea cycle genes (ASS1, ASL, ARG1, ARG2, CPS1, NAGS, NOS2, GPT), and lower expression of pyrimidine synthesis genes (CAD, UMPS, DHODH) in VIP/VIPR1 activation group. (E) Fold change of urea concentration in culture supernatant of different groups in HepG2 and Huh-7 cells. (F) Schematic diagram depicting a regulatory role of VIP/VIPR1 signaling in regulating arginine metabolism and pyrimidine biosynthesis of HCC. Abbreviations: Con.: concentration; n.s.: not significant. Values represent means±SEM. *P< 0.05, **P< 0.01.