Figure 1.

CRISPR library screening identified crucial genes for Lenvatinib resistance at different stages of tumor growth and metastasis. (A) Schematic diagram illustrating the workflow of genome-wide CRISPR/Cas9 knockout library screening both in vivo and in vitro. (B) Pearson correlation coefficient of the normalized sgRNA read counts from the hGeCKOa plasmid library. (C) Number of unique sgRNAs in the samples. (D) Boxplot of the sgRNA normalized read counts for the hGeCKOa plasmid pool. (E) Cumulative probability distribution of library sgRNAs.