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. 2022 Jul 4;18(11):4357–4371. doi: 10.7150/ijbs.69969

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DUSP4 depletion enhanced Lenvatinib resistance by activating the MAPK/ERK pathway. (A) The KEGG pathway analysis showed that DUSP4 participated in Pathways in cancer, Cytokine-cytokine receptor interaction, Regulation of actin cytoskeleton and other pathways related cancer progression. (B-C) The GSEA enrichments demonstrated that DUSP4 is enriched in drug metabolism, Peroxisome, Regulation of actin cytoskeleton and Cell adhesion molecules. (D) The GeneMANIA network showed that DUSP4 is closely associated with MAPK family. (E) protein-protein interaction network revealed that DUSP4 is closely related to DUSP family and MAPK family.