Figure 7.

Selumetinib, a MEK1/2 inhibitor, reversed DUSP4 loss associated Lenvatinib resistance in vivo. (A and B) Both Lenvatinib and Selumetinib could slightly inhibited KO-DUSP4 HCC tumorigenicity. Lenvatinib and Selumetinib combination therapy effectively abolished HCC growth in the nude mice model. (C) The body weights of mice in the three drug-treated groups remained unchanged. Lenvatinib and Selumetinib combination therapy obviously reduced tumor volumes (D) and tumor weights (E). Student's t-test *P < 0.05, **P < 0.01.