Figure 8.
DUSP4 loss is associated with response to Lenvatinib and prognosis. (A) The expression of DUSP4 was downregulated in HCC tissues. (B) Representative images of DUSP4 staining in HCC specimens. (C) There was no significant difference in DUSP4 expression among HCC tissues, normal liver tissues or biopsies of HCC patients before lenvatinib treatment. (D) Responders to lenvatinib treatment showed higher DUSP4 expression levels than nonresponders. (E and F) Low expression levels of DUSP4 were associated with poor OS and DFS. *** represents p< 0.001.