Table 1. Cell Painting Activity Score (Grit) for Published PROTACs.

		grit score at different concentrations (μM)
compound name	target	0.1	1	10
MZ1	BRD4	1.60	3.84	dead cells
ZXH 3–26	BRD4	0.92	2.19	4.31
AT1	BRD4	1.22	2.15	4.20
dBET1	BRD4	–0.47	1.27	2.34
BSJ-03-123	CDK6	0.81	2.78	2.17
BSJ-03-204	CDK4/6	1.17	2.39	1.69
BSJ-04-132	CDK4	0.91	1.20	1.82
CM11	VHL	0.92	0.15	1.95
CRBN-6-5-5-VHL	CRBN	1.03	2.04	2.63
THAL-SNS-032	CDK9	–0.69	2.59	5.42
TL 13-12	ALK	2.08	1.50	5.46
lenalidomide	IKZF1, IKZF3	0.56	0.32	–0.18
pomalidomide	IKZF1, IKZF3	0.46	0.45	–0.02