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. Author manuscript; available in PMC: 2022 Jul 19.
Published in final edited form as: Pharm Res. 2022 Mar 3;39(7):1587–1598. doi: 10.1007/s11095-022-03218-w

Fig. 1. Pharmacokinetic profile of peptidomimetic Nln activators up to 60 min after IV bolus injection.

Fig. 1

(A) Plasma concentration-time profile of Nln activators showed biexponential decline. (B) Brain uptake clearance (Kin) of Nln activators using single time point analysis. 11a showed the highest brain concentration and brain uptake clearance compared to other compounds. Data are presented as mean ± SD of 4 animals per compound. In all cases, p < 0.05 was considered significant.