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Nln Activators’ Distribution in the CNS using Brain Slice Uptake
| Vu, brain (mL/g) | Vu,cell (mL/g) | Kp,uu,cell | %Unbound passing from plasma to brain | |
|---|---|---|---|---|
| 9d | 47.23 ± 8.1 | 8.29 ± 0.35 | 7.88 ± 1.16 | 3.5 ± 0.75 |
| 10c | 101.26 ± 18.27 | 23.06 ± 0.54 | 6.28 ± 0.56 | 1.37 ± 0.51 |
| 11a | 71.03 ± 9.16 | 20.65 ± 0.44 | 5.1 ± 0.45 | 4.8 ± 0.75 |
Data represents the mean ± SD of 3 independent experiments (6–8 brain slices/compound/experiment)
