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In Vitro and in Vivo Drug Development Parameters of Compound 11a
| Structure | LogP (octanol-water) | fu Brain and plasma | Pe in-vitro (cm/sec) | Kin 30 min(μL.g−1.min−1) | A50 (μ) | Brain concentration 30 min (μM) |
|---|---|---|---|---|---|---|
|
1.14 ± 0.1 | 0.062 ± 0.011 & 0.41 ± 0.081 | 18.97 ± 0.9 × 10−6 | 5.03 ± 1.01 | 7 ± 1.76 | 0.26 ± 0.07 |
Data represents the mean ± SD (n = 4–6)
