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. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: J Med Chem. 2021 Aug 26;64(17):12705–12722. doi: 10.1021/acs.jmedchem.1c00759

Figure 1.

Figure 1.

Illustrative workflow of a VS of 139,725 ‘drug-like’ compounds from the NCI Developmental Therapeutics Program (DTP) Library employing the crystal structure of Nln (PDB ID: 1I1I) identified 40 top scorers that were tested in an isolated Nln activation assay to obtain the four hit compounds depicted.