Skip to main content
. Author manuscript; available in PMC: 2022 Sep 9.
Published in final edited form as: J Med Chem. 2021 Aug 26;64(17):12705–12722. doi: 10.1021/acs.jmedchem.1c00759

Figure 3.

Figure 3.

Apical to basolateral transport of Nln activators at 10 μg/mL across an in vitro co-culture model of the BBB at 37 °C illustrates the increased brain permeability of peptidomimetic compounds 9d, 10c, and 11a. The permeability coefficient (Pe) was calculated from the cleared volume of each compound versus time. Values represent the mean ± SD of 3–4 measurements. Statistics: One-way ANOVA followed by Dunnett’s test for comparison of multiple groups with compound 1, p < 0.05 was used as the statistical significance level.