Table 3.
Half-Lives of Selected Nln Activators in Mouse Blood Plasma and Brain Homogenate Illustrate Increased Stability for Peptidomimetic Compounds 9d, 10c, and 11aa
| compound | A50 (μM; 95% CI) | t1/2 (min) mouse plasma | t1/2 (min) mouse brain |
|---|---|---|---|
| 1 (His–Tyr) | 85.5 (65.1 to 112.2) | 34.19 ± 1.97 | 1.03 ± 0.4 |
| 4 (His–Trp) | 39.4 (27 to 57.4) | >300 | 1.55 ± 0.37 |
| 9d | 6.3 (4.3 to 9.2) | >1000 | 65.5 ± 4.2 |
| 10c | 4.2 (3.17 to 5.6) | >1000 | 80.3 ± 2 |
| 11a | 7.0 (4.9 to 9.9) | 248.25 ± 28.1 | 181.55 ± 14.9 |
a
Data expressed as the mean of three experiments ± SD.