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Fraction Unbound ( f u ) in Mouse Plasma and Brain Homogenate of the Selected Nln Activators a
| compound | A50 (μM; 95% CI) | fu in plasma | fu in brain |
|---|---|---|---|
| 1 (His–Tyr) | 85.5 (65.1 to 112.2) | 0.66 ± 0.08 | N.D.b |
| 4 (His–Trp) | 39.4 (27 to 57.4) | 0.93 ± 0.13 | N.D. |
| 9d | 6.3 (4.3 to 9.2) | 0.63 ± 0.076 | 0.14 ± 0.012 |
| 10c | 4.2 (3.17 to 5.6) | 0.45 ± 0.013 | 0.052 ± 0.003 |
| 11a | 7.0 (4.9 to 9.9) | 0.41 ± 0.081 | 0.062 ± 0.011 |
Data expressed as the mean of three experiments ± SD.
Not determined.
