Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 19;24:170. doi: 10.1186/s13075-022-02860-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Enhanced NETosis markers in pSS patients. A Comparison of the fluorescence intensity (FI) of plasma cf-DNA between pSS patients (n=22) and matched healthy controls (n=16), each point represented the fluorescence intensity results of every subjects. B Comparison of the plasma MPO levels between pSS patients, matched healthy controls, and pSS patients after treatment, each point represented the fluorescence intensity results of every subject. C The correlation between plasma cf-DNA and MPO levels. D Comparison of plasma cf-DNA levels and MPO levels between patients with high IgG (n=10) or normal IgG (n=7) levels. E Comparison of Plasma cf-DNA levels and MPO levels between patients with high activity (n=9) or low activity (n=8), patients’ disease activity was assessed through ESSDAI (High activity, ESSDAI>5; low activity, ESSDAI≤5). F,G Comparison of plasma-stimulated neutrophils from pSS and HC to produce NETosis markers, F the fluorescence intensity of cf-DNA; G MPO production levels. H NETosis markers staining in pSS and HC labial glands (×40, blue for DAPI, red for MPO, green for CitH3). *P-value < 0.05, **P-value < 0.01, ***P-value <0.001)