TABLE 1.

Characteristics of Patients With Initial Listing AFP Levels Between 100 and 999 ng/mL Stratified by AFP at LT Category

	AFP at LT Category
Patient Characteristics	Overall, n = 1766	<100, n = 436	100 to 499, n = 334	≥500, n = 109	1-Value, n = 887	P Value
Demographics/clinical
Male sex, %	71.6	70.2	68.9	72.5	73.3	0.40
Race/ethnicity, %						<0.001
Caucasian	58.3	54.1	52.1	54.1	63.3
Asian	10.2	14.9	9.0	14.7	7.9
Hispanic	15.5	16.1	19.8	17.4	13.3
Black	14.8	12.8	17.7	13.8	14.8
Other	1.2	2.1	1.5	0.0	0.8
Etiology, %						0.05
HCV	64.6	66.7	70.1	64.2	61.4
HBV	6.4	7.8	4.5	8.3	6.2
Alcohol	4.1	13.7	5.4	3.8	4.6
Autoimmune	2.8	1.8	2.1	0.0	3.0
NASH	2.5	1.3	1.2	2.8	2.8
Cryptogenic/other	19.7	17.0	16.8	21.1	21.9
At listing
Age, years	57 (53–62)	58 (53–61)	58 (53–62)	57 (51–61)	57 (53–63)	0.19
AFP ng/mL	226 (144–386)	197 (133–339)	206 (142–319)	518 (306–672)	222 (146–393)	<0.001
MELD-Na	10 (8–15)	10 (8–13)	10 (8–14)	10 (8–15)	10 (8–16)	<0.001
CTP class, %						<0.001
A	41.8	47.9	44.6	33.9	38.6
B	45.0	44.3	46.7	48.6	44.4
C	13.2	7.8	8.7	17.4	17
Total tumor diameter, cm	2.9 (2.2–3.8)	2.7 (2.1–3.6)	2.8 (2.1–3.7)	2.4 (1.8–3.5)	3.0 (2.3–4.0)	<0.001
Total tumor number	1 (1–2)	1 (1–1)	1 (1–2)	1 (1–2)	1 (1–2)	0.10
At transplant
Age, years	58 (54–63)	59 (55–62)	59 (54–63)	58 (53–61 )	57 (53–63)	0.01
AFP ng/mL	172 (100–335)	29 (10–60)	200 (140–280)	887 (633–1694)	222 (146–393)	<0.001
Waitlist time, months	2.9 (1.0–6.4)	7.0 (4.6–11.3)	5.6 (4.0–8.5)	5.6 (3.8–8.6)	1.0 (0.5–1.8)	<0.001
Received LRT, %	68.4	91.3	83.2	68.8	51.4	<0.001
MELD-Na	11 (9–1 7)	11 (8–17)	11 (9–17)	14 (9–18)	11 (9–1 7)	0.26
CTP class, %						0.13
A	35.4	39.2	35.3	30.3	34.2
B	44.2	42.9	45.5	40.4	44.8
C	20.4	17.9	19.2	29.4	21.1
Total tumor diameter, cm	2.6 (1.5–2.7)	1.5 (0.0–3.0)	2.3 (1.0–3.4)	2.6 (1.3–3.9)	3.0 (2.2–4.0)	<0.001
Total tumor number	1 (1–2)	1 (1–1)	1 (1–2)	1 (1–2)	1 (1–2)	<0.001
DRI	1.4 (1.1–1.7)	1.4 (1.1–1.7)	1.5 (1.2–1.7)	1.5 (1.2–1.7)	1.4 (1.1–1.7)	0.32

NOTE: Continuous variables are presented as median (IQR).