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. 2022 Jul 19;228(1):68.e1–68.e12. doi: 10.1016/j.ajog.2022.07.014

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Omicron Spike-specific antibody transfer to the umbilical cord after third trimester boosting

A, The dot plots show IgA and IgM against Spike in M and C blood. The lines connect matched maternal-to-cord dyads (n=15), triple asterisks denote P<.001 and four asterisks denote P<.0001 (ns). B–C, The dot plots show the IgG1 (B) and FcR-binding (C) titer against Omicron Spike in M and C blood. The lines connect matched maternal-to-cord dyads (n=15). Significance was determined by a Wilcoxon signed-rank test followed by a Benjamini-Hochberg correction for multiple testing, single asterisk denotes P<.05 (ns). D, The scatter plot shows the correlation of log-transformed cord IgG1 levels against Omicron Spike vs days from maternal booster to delivery. The r value reflects a Spearman correlation.

C, cord blood; FcR, Fc receptor; IgA, immunoglobulin A; IgG1, immunoglobulin G1; IgM, immunoglobulin M; M, maternal blood; ns, not significant.

Atyeo. Antibody response to COVID-19 booster dose in pregnancy. Am J Obstet Gynecol 2023.