Table 1.
The Baseline clinical characteristics of eICU-CRD and MIMIC-IV patients
| eICU-CRD | MIMIC-IV | |||||||
|---|---|---|---|---|---|---|---|---|
| Total (n = 16127) | HCT-ALB < 6.7 (n = 9899) | HCT-ALB ≥ 6.7 (n = 6238) | P value | Total (n = 3043) | HCT-ALB < 6.7 (n = 1970) | HCT-ALB ≥ 6.7 (n = 1073) | P value | |
| Age | 76 (70,83) | 76 (70,83) | 76 (70,83) | 0.532 | 75 (69,82) | 75 (69, 81) | 76 (70, 82) | 0.048 |
| HCT (%) | 30.8 (27.0,35.4) | 28. (25.7,32.6) | 34.3 (30.4,38.8) | < 0.001 | 32.0 (27.6,36.3) | 29.7 (25.9, 33.5) | 36.3 (32.9, 40.1) | < 0.001 |
| ALB (g/L) | 27.0 (22.0,32.0) | 29.0 (25.0,34.0) | 22.0 (19.0,26.0) | < 0.001 | 28.0 (24.0,32.0) | 30.0 (26.0, 34.0) | 24.0 (21.0, 28.0) | < 0.001 |
| SOFA | 7 (5,9) | 7 (5,9) | 7 (5,9) | < 0.001 | 7 (5,10) | 7 (4, 10) | 8 (5, 11) | < 0.001 |
| Gender (%) | 0.010 | 0.445 | ||||||
| Male | 8607 (53.4) | 5198 (52.6) | 3409 (54.6) | 1686 (55.4) | 1102 (55.9) | 584 (54.4) | ||
| Female | 7520 (46.6) | 4691 (47.4) | 2829 (45.4) | 1357 (44.6) | 868 (44.1) | 489 (45.6) | ||
| BMI (%) | < 0.001 | 0.322 | ||||||
| Underweight | 828 (5.1) | 449 (4.5) | 379 (6.1) | 154 (5.1) | 89 (4.5) | 65 (6.1) | ||
| Normalweight | 5110 (31.7) | 3022 (30.6) | 2088 (33.5) | 965 (31.7) | 628 (31.9) | 337 (31.4) | ||
| Overweight | 4520 (28.0) | 2843 (28.7) | 1677 (26.9) | 876 (28.8) | 573 (29.1) | 303 (28.2) | ||
| Obese | 5669 (35.2) | 3575 (36.2) | 2094 (33.6) | 1048 (34.4) | 680 (34.5) | 368 (34.3) | ||
| Ventilation (%) | < 0.001 | 0.001 | ||||||
| No | 11,202 (69.5) | 7061 (71.4) | 4141 (66.4) | 356 (11.7) | 259 (13.1) | 97 (9.0) | ||
| Yes | 4925 (30.5) | 2828 (28.6) | 2097 (33.6) | 2687 (88.3) | 1711 (86.9) | 976 (91.0) | ||
| Dialysis (%) | < 0.001 | 0.712 | ||||||
| No | 14,389 (89.7) | 8656 (87.4) | 5743 (92.1) | 2724 (89.5) | 1760 (89.3) | 964 (89.8) | ||
| Yes | 1738 (10.3) | 1243 (12.6) | 495 (7.9) | 319 (10.5) | 210 (10.7) | 109 (10.2) | ||
| Vasopressor (%) | < 0.001 | < 0.001 | ||||||
| No | 11,271 (69.9) | 7205 (72.8) | 4066 (65.2) | 1218 (40.0) | 859 (43.6) | 359 (33.5) | ||
| Yes | 4856 (30.1) | 2684 (27.2) | 2172 (34.8) | 1825 (60.0) | 1111 (56.4) | 714 (66.5) | ||
| Congestive heart Failure | < 0.001 | 0.040 | ||||||
| No | 12,162 (75.4) | 7310 (73.9) | 4852 (77.8) | 1712 (56.3) | 1081 (54.9) | 631 (58.8) | ||
| Yes | 3965 (24.6) | 2579 (26.1) | 1386 (22.2) | 1331 (43.7) | 889 (45.1) | 442 (41.2) | ||
| Chronic pulmonary disease (%) | 0.941 | 0.450 | ||||||
| No | 12,804 (79.4) | 7849 (79.4) | 4955 (79.4) | 2108 (69.3) | 1355 (68.8) | 753 (70.2) | ||
| Yes | 3323 (20.6) | 2040 (20.6) | 1283 (20.6) | 935 (30.7) | 615 (31.2) | 320 (29.8) | ||
| Diabetes (%) | < 0.001 | 0.001 | ||||||
| No | 13,409 (83.1) | 8097 (81.9) | 5312 (85.2) | 1923 (63.2) | 1204 (61.1) | 719 (67.0) | ||
| Yes | 2718 (16.9) | 1792 (18.1) | 926 (14.8) | 1120 (36.8) | 766 (38.9) | 354 (33.0) | ||
| Renal disease (%) | < 0.001 | < 0.001 | ||||||
| No | 14,669 (91.0) | 8867 (89.7) | 5802 (93.0) | 2025 (66.5) | 1240 (62.9) | 785 (73.2) | ||
| Yes | 1458 (9.0) | 1022 (10.3) | 436 (7.0) | 1018 (33.5) | 730 (37.1) | 288 (26.8) | ||
| Malignant cancer (%) | 0.314 | 0.006 | ||||||
| No | 12,699 (78.7) | 7761 (78.5) | 4938 (79.2) | 2428 (79.8) | 1542 (78.3) | 886 (82.6) | ||
| Yes | 3428 (21.3) | 2128 (21.5) | 1300 (20.8) | 615 (20.2) | 428 (21.7) | 187 (17.4) | ||
| Liver disease (%) | < 0.001 | 0.271 | ||||||
| No | 15,352 (95.2) | 9,461 (95.7) | 5891 (94.4) | 2586 (85.0) | 1685 (85.5) | 901 (84.0) | ||
| Yes | 775 (4.8) | 428 (4.3) | 347 (5.6) | 457 (15.0) | 285 (14.5) | 172 (16.0) | ||
| Metastatic solid tumor (%) | 0.069 | 0.247 | ||||||
| No | 15,591 (96.7) | 9,581 (96.9) | 6010 (96.3) | 2779 (91.3) | 1790 (90.9) | 989 (92.2) | ||
| Yes | 536 (3.3) | 308 (3.1) | 228 (3.7) | 264 (8.7) | 180 (9.1) | 84 (7.8) | ||
| ICU mortality (%) | < 0.001 | < 0.001 | ||||||
| No | 13,899 (86.2) | 8766 (88.6) | 5133 (82.3) | 2377 (78.1) | 1601 (81.3) | 776 (72.3) | ||
| Yes | 2228 (13.8) | 1123 (11.4) | 1105 (17.7) | 666 (21.9) | 369 (18.7) | 297 (27.7) | ||
| Hospital mortality (%) | < 0.001 | < 0.001 | ||||||
| No | 12,585 (78.0) | 8128 (82.2) | 4457 (71.4) | 2065 (67.9) | 1391 (70.6) | 674 (62.8) | ||
| Yes | 3542 (22.0) | 1761 (17.8) | 1781 (28.6) | 978 (32.1) | 579 (29.4) | 399 (37.2) | ||
Continuous variables were expressed by median (interquartile), categorical variables were expressed by count (percentage)
P values were calculated to compare difference between HCT-ALB groups for each dataset separately