Table 3.

Subgroup analysis for association between HCT-ALB group and outcomes for eICU-CRD

		ICU mortality			Hospital mortality
Subgroups	N	OR (95%CI)	P value	P—interaction	OR (95%CI)	P value	P—interaction
Total	16,127	1.50 (1.36, 1.65)	< 0.001	/	1.71 (1.58, 1.87)	< 0.001	/
Age				0.390			0.861
65–80	10,624	1.60 (1.41, 1.80)	< 0.001		1.76 (1.59, 1.96)	< 0.001
> 80	5503	1.43 (1.22, 1.69)	< 0.001		1.73 (1.52, 1.98)	< 0.001
Gender				0.353			0.208
Male	8607	1.43 (1.25, 1.64)	< 0.001		1.63 (1.46, 1.83)	< 0.001
Female	7052	1.57 (1.36, 1.82)	< 0.001		1.82 (1.62, 2.06)	< 0.001
SOFA				0.064			0.040
< 6	5592	1.65 (1.29, 2.11)	< 0.001		1.89 (1.59, 2.26)	< 0.001
≥ 6	10,535	1.50 (1.30, 1.67)	< 0.001		1.70 (1.55, 1.68)	< 0.001
BMI				0.324			0.658
Underweight	828	1.93 (1.29, 2.91)	0.001		1.86 (1.35, 2.61)	< 0.001
Normalweight	5110	1.55 (0.68, 3.60)	0.299		2.00 (1.13, 3.56)	0.017
Overweight	4520	1.78 (0.95, 3.35)	0.007		2.32 (1.51, 3.95)	< 0.001
Obese	5669	1.91 (1.20, 3.02)	0.006		2.01 (1.45, 2.78)	< 0.001
Congestive heart failure				0.809			0.499
No	12,162	1.48 (1.32, 1.66)	< 0.001		1.69 (1.54, 1.86)	< 0.001
Yes	3965	1.54 (1.27, 1.88)	< 0.001		1.81 (1.54, 2.14)	< 0.001
Chronic pulmonary disease				0.753			0.262
No	12,804	1.49 (1.33, 1.69)	< 0.001		1.68 (1.53, 1.85)	< 0.001
Yes	3323	1.56 (1.26, 1.94)	< 0.001		1.87 (1.56, 2.23)	< 0.001
Diabetes				0.577			0.621
No	13,409	1.54 (1.39, 1.72)	< 0.001		1.73 (1.53, 1.89)	< 0.001
Yes	2718	1.66 (1.33, 2.05)	< 0.001		1.72 (1.38, 2.13)	< 0.001
Renal disease				0.387			0.206
No	14,669	1.49 (1.34, 1.65)	< 0.001		1.70 (1.56, 1.85)	< 0.001
Yes	1458	1.65 (1.17, 2.32)	< 0.001		1.99 (1.50, 2.66)	< 0.001
Malignant cancer				0.984			0.721
No	12,699	1.49 (1.34, 1.67)	< 0.001		1.71 (1.55, 1.88)	< 0.001
Yes	3428	1.47 (1.21, 1.81)	< 0.001		1.76 (1.49, 2.09)	< 0.001
Liver disease				0.735			0.435
No	15,352	1.50 (1.36, 1.67)	< 0.001		1.71 (1.57, 1.86)	< 0.001
Yes	775	1.39 (0.97, 2.01)	0.073		1.99 (1.44, 1.78)	< 0.001
Metastatic solid tumor				0.953			0.324
No	15,591	1.50 (1.35, 1.66)	< 0.001		1.70 (1.57,1.86)	< 0.001
Yes	536	1.51 (0.92, 2.48)	0.104		2.21 (1.47, 3.34)	< 0.001

Multivariate models were adjusted by Age, Gender, BMI group, SOFA score, Ventilation, Dialysis, Vasopressor use, Comorbidities (CHF, Chronic Pulmonary Disease, Diabetes, Renal disease, Malignant cancer, Liver disease, and Metastatic solid tumor), excluding models belonging subgroup variate

BMI subgroup were defined as underweight (BMI < 18.5 kg/m²), normal weight (18.5–24.9 kg/m²), overweight (25.0–29.9 kg/m²), and obese (≥ 30.0 kg/m²)

OR odds ratio, CI confidence interval

The OR (95CI%) were calculated when low HCT-ALB (< 6.7) groups set as reference