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. 2021 Nov 5;24(4):359–366. doi: 10.4103/aja202154

Figure 4.

Figure 4

Protein interaction network built from the proteomic dataset using STRING network analysis. The predicted results revealed that SPEF2 can interact with multiple axonemal proteins (SPAG6, RSPH9, SPAG17, etc.), as well as a few IFT proteins (IFT20, IFT27, etc.). In addition, proteins related to ubiquitination process (e.g., UBA1, USP5, and USP14), intramanchette transport (e.g., ODF3 and KIF9), fibrous sheath (AKAP3, AKAP4, and SPA17), and cytoplasmic dynein (e.g., DYNLT1 and DYNLL1) were predicted to interact with SPEF2 or SPAG6. SPAG6: sperm-associated antigen 6; RSPH9: radial spoke head 9; SPAG17: sperm-associated antigen 17; IFT20: intraflagellar transport protein 20; IFT27: intraflagellar transport protein 27; UBA1: ubiquitin-like modifier-activating enzyme 1; USP5: ubiquitin carboxyl-terminal hydrolase 5; USP14: ubiquitin carboxyl-terminal hydrolase 14; ODF3: outer dense fiber protein 3; KIF9: kinesin-like protein KIF9; AKAP3: A-kinase anchor protein 3; AKAP4: A-kinase anchor protein 4; SPA17:, sperm surface protein Sp17; DYNLT1: dynein light chain tctex-type 1; DYNLL1: dynein light chain 1; SPEF2: sperm flagellar protein 2.