TABLE 3.
Parameter estimates and bootstrap validation of the final population pharmacokinetic model for pyrazinamidea
| Parameters (unit) | Population |
Bootstrap |
|||
|---|---|---|---|---|---|
| Mean | IIV (%) | RSE (%) | Median | 95% CI | |
| Vd/F (L/43 kg) | 30.3 | 13.3 | 3.1 | 30.4 | 28.4 to 32.2 |
| CL/F (L/h/43kg0.75) | 2.54 | 24.5 | 5.6 | 2.54 | 2.28 to 2.83 |
| ka (1/h) | 8.63 | 104 | 23.8 | 8.68 | 5.50 to 14.3 |
| Effect of fed status on ka | 0.36 | 80.1 | 18.4 | 0.36 | 0.25 to 0.51 |
| F (fixed) Effect of fed status on F |
1.00 1.00 |
6.9 |
1.6 |
1.00 |
0.96 to 1.03 |
| No. of compartments | 5.26 | 107 | 24.4 | 5.31 | 2.96 to 8.61 |
| Proportional error (%) | 6.54 | 3.8 | 6.53 | 5.48 to 7.60 | |
a
Vd/F, apparent volume of distribution; CL/F, apparent clearance; ka, absorption rate constant; F, bioavailability; IIV, Interindividual variability; RSE, relative standard error; 95% CI, 95% confidence interval.