TABLE 5.
LSSs of pyrazinamide using the multiple linear regressiona
| Sampling time point (h) |
AUC0–24, LSS to AUC24, LSS calculation | RMSE (%) | MPPE (%) | r2 | ||
|---|---|---|---|---|---|---|
| 1st | 2nd | 3rd | ||||
| 0 | −0.309 + 6.863*C0 | 12.72 | −3.03 | 0.9946 | ||
| 2 | 0.046 + 5.945*C2 | 6.47 | 0.22 | 0.9979 | ||
| 6 | 0.297 + 5.804*C6 | 8.84 | 2.21 | 0.9969 | ||
| 0 | 2 | −0.147 + 2.384*C0 + 3.899*C2 | 6.14 | −1.33 | 0.9986 | |
| 0 | 6 | −0.073 + 2.996 *C0+ 3.299*C6 | 5.42 | −0.63 | 0.9986 | |
| 2 | 6 | 0.082 + 3.344*C2 + 2.560*C6 | 4.73 | 0.64 | 0.9990 | |
| 0 | 2 | 6 | −0.057 + 1.653*C0 + 2.333*C2+ 2.159*C6 | 3.97 | −0.47 | 0.9993 |
a
AUC0–24, LSS to AUC24, LSS, area under the 24-h concentration–time curve; C, concentration; RMSE, root mean squared error; MPPE, mean percentage prediction error.