TABLE 2.

Population pharmacokinetic model data of cefazolin concentrations of obese patients (n = 14) undergoing bariatric surgery

PK parametera	Units	Mean	SD	CV%	Median	Shrink%
CL	L · h−1	32.4	20.2	62.2	37.4	0.115
Vc	L	18.2	3.31	18.2	17.7	0.629
Vm	L	5.21	0.948	18.2	4.50	0.268
K ct	h−1	0.164	0.079	48.0	0.182	1.97
K tc	h−1	0.941	0.370	39.4	1.03	3.18
K cp	h−1	5.93	4.01	67.6	4.23	1.24
K pc	h−1	7.21	5.14	71.3	9.71	0.101
K on	L · mg−1 · h−1	0.389	0.176	45.3	0.335	0.080
K off	h−1	16.3	4.96	30.4	14.4	0.251
B max	mg	2,708	584	21.6	2,672	NA

^aPK, pharmacokinetic; CL, clearance of unbound cefazolin; V_c, central volume of distribution of cefazolin; V_m, volume of distribution of cefazolin in the intersitial fluid microdialysis compartment; K_ct, rate of transfer from the unbound compartment to a tissue compartment; K_tc, rate of transfer from a tissue compartment to the unbound compartment; K_cp, rate of transfer from the unbound compartment to a peripheral compartment; K_pc, rate of transfer from a peripheral compartment to the unbound compartment; K_on, rate of association binding to albumin (second-order constant); K_off, rate of dissociation binding from albumin (first-order constant); B_max, maximum binding amount of cefazolin; CV%, coefficient of variation; Shrink%, model shrinkage; NA, not applicable, calculated based on individual parameter estimates from the final model.