TABLE 1.

Characteristics of the CMC patients included in this study^a

Characteristic	Patient 1	Patient 2	Patient 3	Patient 4
Age (yrs) at enrollment	43	42	46	47
Gender	Female	Female	Female	Female
Ethnicity	Caucasian	Hispanic	Caucasian	Caucasian
Underlying CMC syndrome	STAT3 DN	STAT3 DN	Esophageal candidiasis	STAT3 DN
Duration of infection (yrs)	41	41	27	40
OPC	+	+	–	+
EC	–	–	+	–
VVC	+	–	–	–
Primary type of candidiasis	OPC	OPC	EC	OPC
Other infections	Staphylococcus aureus SSTIs, bacterial sinopulmonary infections, chronic pulmonary Pseudomonas	S. aureus SSTIs, bacterial sinopulmonary infections, S. aureus paraspinal abscess	Varicella pneumonia during pregnancy, bacterial pneumonia	S. aureus SSTIs, bacterial sinopulmonary infections, pulmonary chronic E. coli, pulmonary aspergillosis, osteomyelitis (organism unknown)

^aCMC, chronic mucocutaneous candidiasis; STAT3, signal transducer and activator of transcription 3; STAT3 DN, Hyper-IgE syndrome caused by dominant negative STAT3 mutations (Job’s syndrome); OPC, oropharyngeal candidiasis; EC, esophageal candidiasis; VVC, vulvovaginal candidiasis; SSTI, skin and soft tissue infection.