TABLE 2.
MICs of Candida strains to AMB and other antifungal agentsa
Characteristic | MICs (mg/L) |
|||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patient | ||||||||||||||
1 | 2 | 3 | 4 | |||||||||||
Isolation site | Oral | Vagina | Oral | Oral | Eso | Toe | Oral | Fingernail | Oral | Oral | Eso | Eso | Oral | Oral |
Isolated species | Ca | Ca | Ca | Ca | Ca | Ca | Ca | Ch | Ca | Cg | Ca | Cg | Ca | Ca |
Time of analysis | Baseline | On CAMB therapy | Baseline | On CAMB therapy | Baseline | End of CAMB therapy | Baseline | End of CAMB therapy | ||||||
Antifungal agent | ||||||||||||||
AMB | 1 | 0.25 | 0.5 | 1 | 0.25 | 0.25 | 0.25 | 4 | 0.5 | 0.25 | 0.5 | 1 | 0.5 | 0.5 |
Anidulafungin | 0.5 | 0.03 | 0.5 | <0.015 | <0.015 | <0.015 | <0.015 | 0.12 | 0.03 | <0.015 | 0.015 | 0.03 | <0.015 | 0.03 |
Caspofungin | 2 | 0.12 | 2 | 0.03 | 0.06 | 0.03 | 0.015 | 0.25 | 0.03 | 0.06 | 0.015 | 0.03 | 0.12 | 0.03 |
Micafungin | 0.5 | 0.06 | 1 | 0.015 | 0.015 | 0.015 | 0.015 | 0.25 | <0.008 | 0.015 | <0.008 | 0.015 | 0.015 | 0.03 |
Fluconazole | 128 | 256 | 128 | 32 | 16 | 64 | 32 | 128 | 8 | 64 | 8 | 32 | 64 | 32 |
Posaconazole | 2 | 8 | >8 | 2 | 1 | 8 | 2 | 1 | 0.25 | 2 | 0.25 | 2 | >8 | 2 |
Voriconazole | 2 | 4 | 4 | 1 | 2 | 1 | 1 | 1 | 0.12 | 2 | 0.12 | 0.5 | 2 | 1 |
MIC, minimum inhibitory concentration; AMB, amphotericin B; CAMB, cochleated amphotericin B; Ca, Candida albicans; Ch, Candida haemulonii; Cg, Candida glabrata; Eso, esophagus.