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. 2022 Jul 5;13:932155. doi: 10.3389/fimmu.2022.932155

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Copyright © 2022 Chan, Lustig, Baumann, Valerius, van Tetering and Leusen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of neutrophil-mediated tumor cell death. The balance of pro-phagocytic and anti-phagocytic signals determines the fate of the tumor cell. Pro-phagocytic signals are elicited by Fc receptor engagement to IgA-opsonized tumor cells, resulting in Fc activation and phosphorylation of downstream ITAM tyrosines. Calreticulin is tethered to the cell surface by membrane glycans and interacts with lipoprotein receptor-related protein 1 (LRP1) receptor expressed on neutrophils. Likewise, SLAMF7 (CD319) binds to macrophage-1 antigen (MAC-1, α_Mβ₂), these interactions promote tumor cell killing by neutrophils. In contrast, overexpression of CD47 on tumor cells interact with SIRPα to inhibit neutrophil activation. Similarly, if expressed, the sialoglycans-Siglec axis, and HLA1 (B2M)-LILRB axis if expressed decrease immune responses, allowing tumor cells to evade immune surveillance.