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. 2022 May 27;119(22):e2122506119. doi: 10.1073/pnas.2122506119

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Copyright © 2022 the Author(s). Published by PNAS

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 2. — BD1-specific compounds from DECLs. (A) Structures of compounds CDD-724 (racemic compound 6a), CDD-786 (compound 6b), and CDD-787 (compound 6c). (B) BRDT-BD1 and BRD4-BD1 inhibition of lead compounds compared to JQ1 (black) as measured by AlphaScreen. (C) Comparative potencies of each compound against the first and second bromodomains of BRDT and BRD4, with BD1, fold selectivity immediately below. GraphPad Prism software was used to generate inhibition fitting curves and to determine IC₅₀ values.