Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Syntheses of DEC-Tec selection hits and tier 1 SAR 6a-6j. Reagents and conditions: i) Methylamine HCl, O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU), N,N-diisopropylethylamine (DIEA), N,N-dimethylformamide (DMF), room temperature, 1 h; ii) 4 M HCl/dioxane, 1 h; iii) Substituted 2-(2-oxo-1,2-dihydroquinolin-6-yl) acetic acid, HATU, DIEA, DMF, 12 h; iv) 10% Piperidine, DMF, 1 h; v) Different substituted picolinic acids, HATU, DIEA, DMF, 12 h.
