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. 2022 May 23;119(22):e2118099119. doi: 10.1073/pnas.2118099119

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Copyright © 2022 the Author(s). Published by PNAS

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 8. — A model for the dynamic RBS selection by the 30S subunit during initiation. The initiation factors (IF1, IF2, and IF3) may bind to the 30S subunit before or after its binding to mRNA. Step 1, association of the 30S subunit to mRNA through SD:anti-SD base pairing. Step 2, movement of the start codon to the proximity of the P site, which is assisted by initiation factors. Step 3, binding of the initiator tRNA to the P site, such that the downstream RBS is placed at around the mRNA entrance site. Step 4, closure of the entrance site if the RBS can be accommodated completely. Step 5, stable 70S IC is formed in the presence of 50S subunits (5a), or the initiator tRNA is dissociated and the reaction is reverted to a previous step (5b). The corresponding FRET states are shown in each step.