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. 2022 Jul 17;11(1):1778–1786. doi: 10.1080/22221751.2022.2095932

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Pathological lesion and quantitative scoring of histopathological changes and viral antigen expression in Omicron BA.1 or Delta inoculated hamsters. (A) Representative gross pathological lesions of animals inoculated with (I) Omicron BA.1 or (II) Delta. Foci (*) of pulmonary consolidation. (B) Percentage of inflamed lung areas detected in HE staining and (C) % of viral antigen-positive lung areas detected in IHC. Significant statistical differences between two groups were calculated with unpaired t-test (*p < 0.05). (D-K) Histopathological changes and viral antigen expression in nasal turbinates and lungs of Omicron BA.1 and Delta inoculated hamsters. (D) H&E staining and (E) IHC of lungs of Syrian golden hamsters, infected with Omicron BA.1. (F) H&E staining and (G) IHC of nasal turbinates of Syrian golden hamsters, infected with Omicron BA.1. (H) H&E staining and (I) IHC of lungs of Syrian golden hamsters, infected with Delta. (J) H&E staining and (K) IHC of nasal turbinates of Syrian golden hamsters, infected with Delta. Bars indicate 20 µm. (D,H) Proportions of neutrophils (striped arrowheads), oedema fluid (white arrowhead) and type II pneumocyte hyperplasia (black arrowhead) can be found in lungs of Omicron BA.1 and Delta inoculated hamsters. (F,J) The nasal turbinates of both Omicron BA.1 and Delta infected animals were characterized by the presence of many neutrophils mixed with cellular debris and fibrin in the lumina of the nasal turbinates (black arrowhead), infiltration with variable numbers of neutrophils in the underlying olfactory mucosa (striped arrowhead) and multifocal attenuation of the olfactory mucosa (white arrowhead).