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. 2022 Jul 13;42(28):5482–5498. doi: 10.1523/JNEUROSCI.0086-22.2022

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Copyright © 2022 Liu et al.

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Figure 10. — Characterizing the role of ICL1 in protein sorting. A, Left, Airyscan images of DIV10 neurons double labeled with Na_v1.2 (V5, green) and Na_v1.6 (HA, magenta); or, right, Na_v1.2 (V5, green) and Na_v1.6(Na_v1.2 ICL1) (HA, magenta) by cotransfection with corresponding plasmids. Scale bar, 5 µm. B, Computer-aided vesicle segmentation. The frame corresponds to the dotted box in A. Scale bar, 2 µm. C, The distribution of physical distances (nearest neighbor) between Na_v1.2- and Na_v1.6-positive vesicle populations (Na_v1.2 as the origin). In the box chart, top and bottom error bars represent the 95th and 5th percentiles, respectively; triangle represents the range from the 25th to 75th percentile; center line represents the median. The 50 nm dotted line is used as the cutoff for colocalization (Co-loc.). Bottom, The colocalization fraction (percentage) is indicated for each cell.