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. 2022 Jul 13;42(28):5482–5498. doi: 10.1523/JNEUROSCI.0086-22.2022

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Copyright © 2022 Liu et al.

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Figure 9. — ABD deletion greatly reduced Na_v1.2 and Na_v1.6 levels in the AIS. A, Switching V5 and HA tags to label Na_v1.2 and Na_v1.6 didn't affect their subcellular distribution patterns. B, After ABD deletion, Na_v1.2 and Na_v1.6 localizations in the AIS are dramatically decreased. Green, V5; red, HA. Arrowheads in A and B indicate the AIS region. Scale bars, A, B, 20 µm. C, Deletion of ABD abolished enrichment of Na_v1.2 and Na_v1.6 in AIS. Error bars represent SEM. Na_v1.2, n = 10 versus Na_v1.2(ΔABD), n = 13, p = 0.0049; Na_v1.6, n = 10 versus Na_v1.6(ΔABD), n = 17, p < 0.0001.