TABLE 3.
Affinity in KD (μM) of human and mouse IgG subclasses for FcγRs.
| FcγR | Human | Mouse | |||||||
|---|---|---|---|---|---|---|---|---|---|
| IgG | hFcγRIIB | hFcγRI | a hFcγRIIA | hFcγRIIIA | mFcγRIIB | mFcγRI | a mFcγRIII | mFcγRIV | |
| Inhibitory | Activating | Activating | Activating | Inhibitory | Activating | Activating | Activating | ||
| Human | bhIgG1(h1) | 3.01 | 0.0052 | 1.16 | 6.7 | 1.1 | 0.035 | 9.3 | 0.28 |
| chIgG2(h2) | 500 | — | 2.2 | 14 | 7.9 | — | 9.7 | — | |
| hIgG4(h4) | 50 | 0.029 | 5.9 | 4 | 11 | 0.19 | 21 | 26 | |
| Mouse | bmIgG2a(m2a) | N/A | N/A | N/A | N/A | 2.5 | 0.0063 | 1.4 | 0.034 |
| cmIgG1(m1) | N/A | N/A | N/A | N/A | 0.303 | — | 3.3 | — | |
| mIgG2b(m2b) | N/A | N/A | N/A | N/A | 0.45 | — | 1.7 | 0.059 | |
—, no binding detected; N/A, not available.
a
hFcγRIIa/mFcγRIII is identified to be orthologous pair between human and mouse; bhIgG1/mIgG2a and chIgG2/mIgG1 are proposed to be functional homologues