Fig. 3.

Viral titre log loss (pfu/mg) of spray dried AdHu5 adenoviral vector with excipient formulations using mannitol with dextran (MD) in a ratio by weight of either 1:3 or 3:1 and either a low molecular weight dextran (40 kDa) or high molecular weight dextran (500 kDa). A xylitol-dextran (XD) formulation with a 1:3 ratio using 40 kDa dextran is also shown. Process loss refers to viral titre loss from spray drying compared to the stock viral titre, while aging losses are associated with the additional viral titre loss after samples were stored at 45°C for 72 h prior to in vitro testing. All samples were tested in duplicate and error bars represent the resulting standard error.