Fig. 5.

Normalized dose of spray dried powder dispersed from custom made dosator device (Fig. 1), for each respective mannitol-dextran formulation in a mass ratio of either 1:3 or 3:1 using a low molecular weight dextran (40 kDa) or high molecular weight dextran (500 kDa). Emitted dose refers to the powder dosage exiting the needle tip of the dosator upon actuation. Delivered dose represents the percentage of powder collected after powder was sprayed from the dosator and directly through a 3D printed mouse trachea, mimicking endotracheal delivery. Both emitted and delivered dose were normalized based on powder mass initially loaded. Error bars represent standard error between replicate measurements (n = 3)