. 2022 Jul 12;2022:1240242. doi: 10.1155/2022/1240242

Table 3.

Differential metabolites in viral pneumonia model mice induced by poly (I:C) after the treatment of XCH.

No.	Formula	RT (min)	m/z	Metabolites	VIP		FC		Trend		Pathway
No.	Formula	RT (min)	m/z	Metabolites	M vs. C	X vs. M	M vs. C	X vs. M	M vs. C	X vs. M	Pathway
1	C₆H₈O₆	1.65	175.02	Ascorbic acid	1.44	1.71	0.64	1.30	↓^##	↑^∗
2	C₆H₁₃O₉P	1.42	259.02	D-glucose 6-phosphate	1.94	1.44	1.95	0.68	↑^##	↓	c
3	C₅H₁₃NO	1.33	104.11	Choline	1.46	1.84	0.65	1.50	↓^#	↑^∗
4	C₁₀H₁₆N₂O₃S	5.35	245.10	Biotin	1.91	2.27	0.47	1.79	↓	↑^∗^∗	g
5	C₆H₁₃O₉P	1.53	259.02	D-mannose 6-phosphate	1.87	1.62	0.73	1.36	↓	↑	b
6	C₄H₉N₃O₂	1.41	132.08	Creatine	1.53	1.44	0.68	1.32	↓^#	↑^∗	d
7	C₆H₁₃NO₅	1.43	180.09	D-glucosamine	2.12	1.24	0.47	1.17	↓^##	↑	b
8	C₆H₁₁NO₂	1.15	130.09	L-pipecolate	2.09	2.10	0.60	1.53	↓^##	↑^∗
9	C₂H₇NO₂S	1.35	110.03	Hypotaurine	1.71	1.55	0.68	1.32	↓^#	↑^∗	f
10	C₈H₈O₄	5.08	167.03	Homogentisic acid	1.55	1.07	1.95	1.33	↑^##	↑	a
11	C₇H₆O₄	5.64	153.02	Gentisic acid	2.34	1.30	0.41	1.73	↓^##	↑	a
12	C₂₄H₄₀O₅	6.61	407.28	Cholic acid	1.15	1.91	1.14	0.17	↑	↓^∗^∗
13	C₂₁H₃₀O₅	5.59	363.22	Hydrocortisone	1.64	1.69	0.54	1.91	↓^#	↑^∗^∗	e
14	C₂₁H₂₈O₅	5.85	361.20	Cortisone	1.76	1.24	0.58	1.46	↓^#	↑^∗	e
15	C₉H₁₃NO₃	5.56	184.10	L-adrenaline	1.20	2.37	0.62	1.27	↓^#	↑	a
16	C₄H₇N₃O	1.38	114.07	Creatinine	1.72	1.30	1.16	0.66	↑	↓^∗
17	C₆H₁₂N₂O₃	1.44	161.09	D-Ala-D-Ala	2.04	1.34	1.68	0.38	↑^##	↓^∗^∗
18	C₅H₉NO₃	1.35	132.07	Hydroxyproline	1.49	1.41	1.43	0.42	↑^#	↓^∗^∗	d
19	C₁₀H₇NO₃	5.38	190.05	Kynurenic acid	2.00	1.18	0.45	0.60	↓^##	↓^∗
20	C₅H₇NO₃	6.39	130.05	Pyroglutamic acid	1.99	1.43	0.34	0.57	↓^##	↓^∗^∗
21	C₂₁H₃₀O₄	6.25	347.22	Corticosterone	1.48	1.45	1.57	0.53	↑^##	↓^∗^∗	e
22	C₂₆H₄₅NO₇S	7.72	516.30	Taurocholic acid	1.69	2.05	0.25	1.87	↓^#	↑^∗^∗	f
23	C₂₀H₃₀O₄	7.37	333.21	Prostaglandin A2	1.82	1.21	1.32	1.56	↑^#	↑^∗^∗
24	C₂₀H₄₀O₂	11.56	311.30	Arachidic acid	1.69	1.69	1.40	0.26	↑^##	↓^∗^∗
25	C₁₆H₃₀O₂	7.85	255.23	Palmitoleic acid	1.48	1.62	0.62	0.87	↓^##	↓

Control, model, and XCH high-dose groups (n = 6 per group). RT: retention time; VIP: variable importance of projection; FC: fold change;^#: p < 0.05 as compared to the control group; ^##: p < 0.01 as compared to the control group; ^∗: p < 0.05 as compared to the model group; ^∗^∗: p < 0.01 as compared to the model group; ↑: content increased; ↓: content decreased; vs.: versus; C: control group; M: model group; X: XCH high-dose group; a: tyrosine metabolism; b: amino sugar and nucleotide sugar metabolism; c: starch and sucrose metabolism; d: arginine and proline metabolism; e: steroid hormone biosynthesis; f: taurine and hypotaurine metabolism; g: biotin metabolism.