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. 2022 Jul 5;12:828439. doi: 10.3389/fcimb.2022.828439

Figure 3.

Figure 3

qRT-PCR determining the effect of overexpression and knock-down of IFITs on expression of IFN-β and IFN-γ in hMDMs infected with (A) M. smegmatis at 12 hours, M. bovis BCG at (B) -12 hours, (C) -96 hours, M. tb R179 at (D) -12hours and (E) -96 hours post infection. Compared to untreated CFUs and knock-down, we found higher expression of IFN-β and IFN-γ in IFITs overexpressed hMDMs. This indicates the association of these two cytokines with reduction of CFUs after knock-up vs. knock-down). ***p<0.0001 (comparison between knock-up vs. knock-down).