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. 2022 Jul 19;79(8):432. doi: 10.1007/s00018-022-04460-6

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Number of age-associated brain protein aggregates correlates with the body weight and metabolic tissue weights of the senescent HIF-P4H-2 deficient mice. A Correlation of wild-type (WT) and Hif-p4h-2^gt/gt (gt/gt) body weight with the number of brain protein aggregates. B, C Correlation of the WAT and liver weight, respectively, with the number of brain protein aggregates. n = 22 WT, 12–13 gt/gt. agg. Aggregate, HPF high-powered field, WAT white adipose tissue