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. 2022 Mar 9;127(2):185–192. doi: 10.1038/s41416-022-01753-2

Fig. 2. Plausible cellular mechanisms mediating hepcidin downregulation in hepatocellular carcinoma (HCC).

Fig. 2

The figure shows alterations in the hepcidin gene (HAMP) and changes in some hepcidin-modulatory proteins in HCC that may be fully or partly responsible for hepcidin downregulation in HCC. Note that BMP6 upregulation in HCC has been observed and this needs to be investigated.