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. 2022 Jul 19;13(7):626. doi: 10.1038/s41419-022-05090-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Pearson correlation coefficient heatmap of quadruplicates indicates reliability of experiment. B Numbers of glycoproteins, glycopeptides, intact N-glycopeptides (IGPs), and glycans identified are presented. C Volcano plots indicate differentially expressed glycoproteins. p < 0.05. D Heatmap shows differentially expressed glycotypes. E Heatmap displays proteins modified by up-regulated glycotypes. Red indicates up-regulation, blue indicates down-regulation, and gray indicates no difference. N is HexNAc, H is Hex. F is Fucose. Cartoon symbols used for glycans (see inset) conform to the standard representation recommended by the Consortium for Functional Glycomics.