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. 2022 Jul 19;13(7):626. doi: 10.1038/s41419-022-05090-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A GDF15 level was determined by ELISA in serum samples from normal and patients with BPH, Localized PCa, or mCRPC. One-way ANOVA, p < 0.05. Data are expressed as mean ± std. B Prostate cancer patient overall survival curve in relation to GDF15 expression level was calculated using data from the Gene Expression Profiling Interactive Analysis (EGPIA) website. C Overall survival curves of lower grade glioma (LGG), mesothelioma (MESO), and uveal melanoma (UVM) patients in relation to GDF15 expression level were obtained from the EGPIA website. P-values were calculated using log-rank test; meta-analysis survival plots were generated using KM plotter. D Schematic graph depicts GDF15 inhibition of EGFR and N-glycosylation of GDF15 disables its suppressive effect on the EGFR pathway in CRPC cells.