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. 2022 May 30;127(2):237–248. doi: 10.1038/s41416-022-01805-7

Fig. 1. HDAC4 upregulation predicts unfavourable prognosis for patients with GC.

Fig. 1

a Heatmap of differentially expressed HDACs in GC based on microarray data sets (Cho). b The expression of HDAC4 between GC and normal tissues in TCGA target GTEx (N, normal tissue; T, tumour tissue). c Venn diagram displaying only HDAC2 and HDAC4 in both Cho, GSE79973, and GEPIA. d, e qRT-PCR was used to detect the expression of HDAC2 and HDAC4 in 20 matched GC samples. f Typical tissue microarray image analysis of HDAC4 expression in 110 patients. Scale bar, 50 μm. g Quantification of HDAC4 expression by immunohistochemistry analysis. h OS and DFS of GC patients related to HDAC4 expression by Kaplan–Meier survival curve analysis (P < 0.001). i OS of GC patients related to HDAC4 expression based on Kaplan–Meier Plotter database. *P < 0.05, **P < 0.01.