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Model schematic for tenofovir disoproxil fumarate and emtricitabine disposition. ka, absorption rate constant; ALAG, lag time; CL, clearance from the central compartment; V2, central compartment volume of distribution; V4, peripheral compartment volume of distribution; Q1, intercompartmental clearance; K23, formation rate constant of metabolite stimulated by plasma drug; K30, elimination rate constant of intracellular metabolite
