Skip to main content
. 2022 Jul 19;13:4174. doi: 10.1038/s41467-022-31825-z

Fig. 5. Stomatin transgenic mice fed with high-fat diet exhibited adipocyte hypertrophy and metabolism disorders.

Fig. 5

a The weights of SAT, VAT and BAT in stomatin transgenic mice STOM Tg or WT mice, fed with regular CD or HFD for 20 weeks were measured. b Representative H&E-stained histopathological sections of SAT, and BAT from HFD-fed STOM Tg or HFD-fed WT mice. Histogram analyses of sizes of adipocytes are shown. Bar = 250 µm. c After HFD-feeding for 20 weeks, the animal’s fasting glucose, serum insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and intraperitoneal glucose tolerance test (IPGTT) were examined. d The mass of liver of STOM Tg or WT mice, fed with HFD for 20 weeks, were weighed. Fatty liver changes revealed by histopathological sections and high level of serum glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT) indicated impaired hepatic functions in STOM Tg mice, compared to WT mice. Bar = 100 µm. a–d Each dot represents one mouse. Mean ± s.d. is shown. n.s = non-significant. *P < 0.05, **P < 0.01, and ***P < 0.001 by multiple unpaired t-test. Source data are provided as a Source data file.