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. 2022 Jul 19;12:12312. doi: 10.1038/s41598-022-16564-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cynomolgus monkey is a suitable species to study the safety of ERY974. (a) Cytotoxicity assay for ERY974 using human PBMCs. (b) Cytotoxicity assay for ERY974 using cynomolgus monkey PBMCs. PBMCs from four independent donors are used as effector cells, and SK-pca13a was used as the target cell. Data are shown as mean ± SD (n = 3). (c) Summary of tissue cross-reactivity of ERY974 in human and cynomolgus monkeys. Frozen sections of various normal tissues from human and cynomolgus monkeys were stained with biotinylated ERY974. Tissues positive for ERY974 staining are shown with “P,” and tissues negative for ERY974 staining are shown with “-.” Cyno means cynomolugus monkey.