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. 2022 Mar 24;127(2):202–210. doi: 10.1038/s41416-022-01784-9

Fig. 2. KAT6A promotes cell viability, proliferation and colony formation of HCC cells in vitro and in vivo.

Fig. 2

a Hep3B and Huh7 cells that were transfected with corresponding KAT6A vectors were subjected to WB for KAT6A expression. Overexpression of KAT6A promoted cell viability (b), proliferation (c) and colony formation (d) in Hep3B cells, while downregulation of KAT6A inhibited cell viability (b), proliferation (c) and colony formation (d) in Huh7 cells. e Tumour growth curve revealed that KAT6A overexpression significantly promoted tumour growth in vivo. Tumour nodules were subjected to immunohistochemical staining for Ki-67 (e) and TUNEL (f) assays and quantitative analysis. Representative immunostaining and TUNEL assays revealed that KAT6A overexpression significantly increased the number of Ki-67-positive cells and inhibited the number of apoptotic cells. *P < 0.05.